Original Article
Prevalence of Hepatitis B & C
at Tehsil Headquarter Hospital in Cataract Surgery Patients
Muhammad Yasser Nisar, Taseer
Salahuddin
Pak J Ophthalmol 2017, Vol. 33, No. 2
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See
end of article for authors
affiliations …..……………………….. Correspondence
to: Dr. Taseer Salahuddin DOMS Eye Specialist Consultant Ophthalmologist at THQ Khanpur E.mail: salahuddin.taseer@gmail.com |
Purpose: To investigate the prevalence
of hepatitis B & C in the patients admitted for cataract surgery at THQ
Khanpur. Study Design: Cross sectional study. Place and Duration of Study: Tehsil
Headquarter Hospital, Khanpur from December 2015 till December 2016. Material and Methods: Patients
were informed and tested for hepatitis B and C via diagnostic tests for
surface antigen HBsAg (Hepatitis B) and anti HCV (C). Based on the positive
results determination of prevalence of hepatitis B, C or both was done. Patient
information was recorded on performa and analyzed. Results: 50 patients were operated for extracapsular
cataract extraction (ECCE) at THQ Khanpur during the period of last one year.
Mean age of the patients was 57 years. Out of 50 patients 27 were females
(54%) and 23 were males (46%). Out of 50 patients, 7 (14%) suffered from
hepatitis B, 8 (16%) from hepatitis C and 3 (6%) from both hepatitis B &
C simultaneously. Thus, 18 out of 50 (36%) patients were positive for either
disease. Conclusions: Incidence of Hepatitis B and C
was higher than the average prevailing rates in Pakistan both in males and
females. Percentage in males was higher than females in the sample. Keywords: Hepatitis B, Hepatitis C,
Extra-Capsular Cataract Surgery. |
There are multiple
variants of hepatitis resulting from different stands of viruses namely A, B,
C, D and E. They result in liver cirrhosis and hepatocellular carcinoma1.
Hepatitis caused due to virus strand B (a DNA virus) is a virus that is life
threatening. Incidence of this type of hepatitis is very high with 3 million
people being carriers, 2 billion being affected at some stage of their lives
and one million dying due to it2. Although this disease prevails at
global level, however, its occurrence is highest in Asia, Africa and Middle
East3. High prevalence of hepatitis C has been recorded by World
Health Organization WHO to be around 3% of global population or 120-170 million
in numbers4. Incidence of both Hepatitis B and C is increasing5,
which is an alarming situation. Both these types of hepatitis have same modes
of transmission, including prenatal transmission, blood transmission, sexual
contacts, drug abuse and use of infected surgical instruments6. Hospitals,
both private and public ones where B & C screening is not being done
especially before surgeries are potential threat in spreading these types of
hepatitis7. Awareness and knowledge for causes and limiting factors
of hepatitis B and C are limited in rural areas and primary health care centers8.
Prevalence of hepatitis B is 10%9 and C is 4-7%10,11 in
Pakistan. Realization of the fact that lack of facilities, screening practice
and knowledge leads to spread of these diseases in patients also risking
surgeons and operating room staff, has led to increased focus of research
towards recording the incidence of hepatitis B and C in urban areas13.
However, in primary care centers in Pakistan there still is a need for research
and focus to the screening and recording the occurrence of these types of
hepatitis needs to be done. Current research helps to fill this gap both from
literature as well as quantitative point of view.
MATERIAL AND METHODS
This was an cross
sectional study carried at THQ hospital Khanpur, district Rahimyar Khan, which
is a secondary care hospital. Here for the very first time since the beginning
of the hospital cataract surgery started last year due to the provision of
surgical equipment by the punjab government. All the patients admitted for
cataract surgery were included in the study. Patients who were admitted for
other surgical procedures like pterygium or extraction of foreign body etc.
were not included. Screening of Hepatitis B and C was kept as a necessary step
before surgery. Each patient was informed and record was kept on the surgery
record register of the surgeon. During one year 50 surgeries were done. All
infected patients were referred to medical specialist for treatment and all
those who had not been vaccinated were advised for vaccination. Furthermore,
separate surgical sets were marked for both types of hepatitis and for each
infected patient same type of labeled surgical sets were used. This was done to
prevent further spread of these diseases during surgeries. Surgeon and O.T
staff took proper precautions for self-safety as well.
RESULTS
As mentioned earlier a total of 50 patients
were operated out of which 27 were females and 23 were males. During analysis
following gender distribution of HbsAg and anti-HCV were observed.
There was a clearly high incidence of B (17.3%) and C
(21.73%) separately in males as compared to females (11.11%) respectively. When
simultaneous incidence of both the types of hepatitis was seen, a comparatively
high percentage (7.04%) of females suffered as compared to males (4.34%).
Along with the incidence of disease non-infected cases
observed were higher in females as compared to males. 70.37% of females were
not infected whereas only 56.52% were not infected. This showed an alarmingly
high concentration of males (almost 45%) who were infected by HbsAg and
anti-HCV.
Gender distribution of
Hepatitis B & C |
|||||
Gender |
Total |
Not infected |
B+ |
C+ |
Both B & C |
Females |
27 |
19 (70.37%) |
3 (11.11%) |
3 (11.11%) |
2 (7.04%) |
Males |
23 |
13 (56.52%) |
4 (17.39%) |
5 (21.73%) |
1 (4.34%) |
Same
situation is evident when a comparative bar chart for genders was drawn for
both Hepatitis B and C.
Furthermore,
a detailed position chart also showed the concentration of more colored columns
of hepatitis B and C in male region as compared to females.
Same was tested for
association by running two slightly different versions of the chi-square
procedure in Minitab version 14, which gave results for the gender and over all
hepatitis B and C prevalence. Results reported by Minitab showed a p-value of 0.000, which
begin below 0.05
is
Pearson Chi-square = 54,367, DF = 1, P-Value = 0.000
Likelihood Ratio Chi-Square = 51.298,
DF = 1, P-Value = 0.000
statistically significant. This means that gender and hepatitis B
& C prevalence are related in a larger population.
Hepatitis B and C increasing incidence is
an emerging problem for developing countries like Pakistan. This issue further
aggravates in primary and secondary health care centers due to lack of proper
protocols and awareness, which is a result of unsafe medical practice13.
In our study a cross gender comparison has been done to investigate the
difference between incidence of hepatitis B & C. Within Pakistan incidence
of HbsAg is around 10%14. Our study has shown this incidence higher
in both females (11.11%) and males (17.39%). This higher incidence in males as
compared to females was also observed in another study by Riaz et al13.
However, for their study B+ prevailed in 7.4% cases as compared to 7% of
females. Similarly, for C positive their results were showing same trends with
much less percentages. As for their results C positive females were 11.2% of
the sample and males were 12.6%, whereas according to our results 11.1% of
females were C+ whereas as high as 21.73% males were C positive. Overall 18 out
of 50 (36%) of the sample was B and C positive. This is more than three times
higher than previously recorded results9,10,11,12,13. It is
therefore, of utmost importance that government pays special attention to this
medical issue at Khanpur. This study also highlights the importance of further
investigation of causes of such high incidence of Hepatitis B and C at Khanpur.
There is also room of exploration of similar studies in other primary and
secondary health care hospitals to see if same trend exists there.
In another study by Abbas Z et al10
a cross-sectional survey having 873
subjects belonging to 174 families residing in Jarwar, a small town of upper
Sindh was done. HBsAg was reactive in 44 (5%), HBcAb in 494 (56.6%) and
anti-HCV in 294 (33.7%). In the case control study, independent risk factors
for exposure to hepatitis B were male sex, age greater than 16 years, absence
of vaccination, previous history of jaundice, and family history of liver
disease. Independent risk factors for hepatitis C were age greater than 16
years, previous dental procedures, history of liver disease, lack of
vaccination, and 10 or more injections in a year. There was indication of
intrafamilial and household clustering: for hepatitis C, parent to child p =
0.001, sibling-to-sibling p = 0.046; for hepatitis B, spouse-to-spouse p =
0.052 and parent to child p = 0.001.
Proper screening and
protocols for limiting the spread of these diseases at least via surgical
procedures was followed at our hospital . This sets an example for other
primary and secondary health hospitals in Pakistan where safe medical
procedures and screening are not being followed. As transmission of HbsAg and
anti-HCV is common via injections, needle pricks and surgical malpractices15-20.
CONCLUSION
Hepatitis B and C have
multiple transmission modes, out of which lack of screening before surgical
processes and unsafe surgical procedures are important ones. If proper
protocols of screening and separating surgical instruments are followed there
will be vast reduction in spread of these diseases. Furthermore, practical
application of screening tests and patient counseling by the surgeons and
medical staffs can be the best awareness scheme for the prevention of both
hepatitis B and C spread.
Authors Affiliation
Dr. Muhammad Yasser
Nisar
DOMS
Eye Specialist
Consultant
Ophthalmologist
THQ Khanpur
Taseer Salahuddin
Mphil, PhD Scholar
National College of
Business
Administration &
Economics
Independent researcher
Role of Authors
Dr. Muhammad Yasser
Nisar
Data collection and Literature
Review
Taseer Salahuddin
Manuscript writing and
data analysis
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